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[08/07/2008] Applied Nutriceuticals In Stock!

RPM™ by Applied Nutriceuticals™ is so unique it’s literally in a class by itself. RPM is the world’s first Anabolic-Cognitive Energy System Enhancer (A-CESE), where anabolics meet cognitive psy-stimulants!  

  

RPM requires a new and different product categorization because it contains testosterone-like, anti-catabolic, and aromatase-inhibiting properties, while at the same time delivering optimal mind/muscle connection/contraction through unique peripheral vasostimulatory effects and increased cognitive psycho-motor control.  No other product on the market today can make this claim. RPM combines P-SARM Synthase AI - a unique blend of research-grade icariin, arginine, naringenin, and oligomeric proanthocyanidins (OPCs), and Methyl-AMP Complex, a powerful blend of methyl-xanthine caffeine and chocamine.

 

Like all of our products, Applied Nutriceuticals uses only the highest quality ingredients in scientifically-proven doses in RPM as to achieve maximum results. It is classified as a Phytochemical Selective Androgen Receptor Modulator (P-SARM), which means that it is a phytochemical (plant-derived) compound that mimics the positive effects of pharmaceutical compounds called SARMs. SARMs (Selective Androgen Receptor Modulators) are a future class of drugs that hold great promise to effectively replace traditional anabolic preparations due to their overall effectiveness and absence of negative side-effects that commonly go hand-in hand with anabolic / androgenic steroids. Like their pharmaceutical cousins, P-SARMs exert none of the negative effects on blood lipids (LDLs) or blood pressure associated with many androgens while having pronounced positive effects on muscle mass, strength, bone growth, drive, and sexual function.  The efficient oral bioavailability and flexible biochemical structure of P-SARMs provide an excellent alternative to black-market enhancement products - with no downside!

 

ICARIIN

 

Icariin is one of the key constituents in the P-SARM Synthase AI component of RPM. Several studies have shown that icariin competes with glucocorticoids for receptor sites in a manner similar to testosterone and improves the testosterone / cortisol ratio. This is caused by several different mechanisms of action; the aforementioned competition with glucocorticoids, via increased testosterone production which is accomplished through increased cAMP (cyclic AMP, a second messenger important in hormone signaling) levels, increased luteininzing hormone (LH) levels, the mimicry of testosterone in spermatogenesis, and decreased prolactin levels.  It has been shown that icariin blocks glucocorticoids from binding to cortisol receptors, hence blocking the actions of cortisol.  This alone creates an anabolic effect by positively skewing the testosterone / cortisol ratio, which is a trigger for greater protein synthesis, increased aggression, and intensified muscle contractions.

 

Users of RPM report huge improvements in strength, physique hardness, and positive aggression while using this compound, an effect that can be at least partially attributed to the androgen-mimicking qualities of icariin. RPM promotes increased dopamine levels and decreased prolactin levels, both of which are triggers for increased testosterone.  Icariin can also enhance muscle contraction by decreasing the effects of acetylcholinesterase (AChE).  Acetylcholine (Ach) is a neurotransmitter necessary for muscle contraction, and AChE is responsible for disabling ACh at the neuromuscular junction.  Icariin blocks this disabling action, allowing for ACh to stay at the synapse and better exert its effects for a longer period of time- thus allowing for harder and stronger muscle contractions.

 

HPTA and Testosterone

 

Icariin is a selective inhibitor of cyclic guanitric oxidesine monitric oxidephosphate (cGMP)- specific phosphodiasterase type 5 (PDE5 for the purpose of this article).  This is a notable characteristic, because PDE5 hydrolyzes cGMP  into an inactive molecule.  cGMP is important because nitric oxide requires cGMP to moderate vascular control and vasodilation.  So essentially, no cGMP; no vasodilation (the “PUMP”), because nitric oxide requires cGMP to work.  Conversely, the more cGMP; the more nitric oxide-induced vasodilation - therefore the greater the pumps. Icariin stops PDE5 from disabling cGMP and allows cGMP to extend its activity which increases the effects of nitric oxide in skeletal muscle and allows for a stronger muscle contraction and pump.  This is the same way a popular pharmaceutical product – Viagra® – works; which is essentially the most well-known PDE5 inhibitor on the market.

 

 

 

In scientific studies, pure icariin has been found to have roughly one-tenth the PDE5 inhibitory activity and nitric oxide productivity of Viagra®, and the dosage provided in RPM is tailored appropriately to provide similar effects.  In short, the PDE5 inhibition displayed by icariin puts RPM in a class above all other nitric oxide enhancers- as “pharmaceutical-strength” results are commonly experienced.

 

 

 

Oligometric Proanthocyanidin

 

Oligomeric proanthocyanidins (OPCs) are essential components of RPM. OPCs have been shown in numerous studies to have the ability to block the conversion of androgens to estrogens (a process known as aromatizing). OPCs are a refined derivative of grape seed extract and exhibit qualities comparable to several widely marketed pharmaceutical aromatase inhibitors (i.e. Arimidex®). Compounds exhibiting aromatase inhibiting characteristics have been shown to reduce SHBG (steroid hormone binding globulin) as well.  This is important because this allows for a dramatic increase in free testosterone, which promotes longer, harder more intense workouts, rapid strength increases, greater protein synthesis, quicker recovery, and increased lipolysis (fat burning). This, coupled with the androgen-mimicking qualities of icariin, gives the product a unique “hardness” enhancing quality unlike anything else available.  

 

OPCs also protect against free radicals and subsequent DNA and oxidative damage, qualities that are extremely important to the hard-training athlete.  Oxidative damage is a common occurrence during stress and hard training, and it can have a halting effect on the subject’s gains in lean body mass.  Less oxidative damage leads to faster recovery which gives you the ability to train longer and harder.  

 

The nitric oxide-enhancing, vasodilatory properties of OPCs have been documented in countless studies.  The flavonitric oxideids contained in OPCs have been shown to increase levels of nitric oxide synthase, the enzyme that allows for the conversion of arginine to nitric oxide.  This is a critical element, because nitric oxide synthase competes with arginase for the utilization of the aminitric oxide acid L-arginine.  Arginase converts L-arginine into ornthine, and increased arginase and ornthine activity is counteractive to the nitric oxide production pathway.  Therefore, by increasing nitric oxide synthase, the flavonitric oxideids in OPCs “crowd out” arginase, allowing for more arginine to be processed into nitric oxide. The result is higher nitric oxide levels and even greater vasodilation, all of which additionally contribute to the unprecedented pumps and muscle hardness that subjects using RPM experience. 

               

Naringin, and its novel component Naringenin, also contribute profound effects within the P-SARM Synthase AI complex.  Naringin (and Naringenin) exhibit remarkable anti-aromatase and estrogen-inhibiting properties by decreasing the cytochrome P450arom isoform, which is an enzyme that also allows for the oxidative metabolism for chemical modification and degradation of oral medications.  This can have very positive effects on the testosterone / estrogen ratio, and the combination of OPCs and naringenin act synergistically in reducing estrogen; allowing for more circulating free testosterone and all of its associated benefits.  Naringin and naringenin have also been shown to enhance the metabolism of caffeine and PDE5 inhibitors such as icariin, allowing for these compounds to be much more effective on a per dose basis - by up to 35%!!! 

 

Action of Anti-Aromatases

 

 

L-Arginine is the last component of the P-SARM Synthase AI matrix.  L-Arginine is an amino acid that is necessary for cell division, injury healing, ammonia displacement, hormone release, and immune function. Most importantly, L-arginine is necessary for the production of nitric oxide. As mentioned earlier, nitric oxide is derived from arginine and oxygen through a process called nitric oxide synthase, and exerts its effects on tissue through cGMP.  The inclusion of Arginine in the P-SARM Synthase AI complex allows for a steady, continuous supply of L-arginine for conversion to nitric oxide, allowing for a more effective product.  Numerous research studies document the positive effects of L-Arginine and nitric oxide on increasing lean body mass, and possibly even mediating greater growth hormone response.

 

Methyl-Xanthine Anhydrous Caffeine (MXAC) is the first component of the Methyl-AMP Complex and is a metabolic stimulant that heightens mental alertness and focus and improves muscle contraction and coordination.  MXAC also exerts very strong effects on vasodilation in a process that begins with the activation of norepinephrine and the deactivation of cAMP-PDE (the enzyme that breaks down cAMP). When MXAC acts on a cell, cAMP-PDE can no longer turn cAMP into AMP, so the action of cAMP is prolonged within the cell. When cAMP levels are increased, the blood vessels in skeletal muscle tend to relax and dilate. The result is more voluminous blood flow into the muscle, resulting in bulging vascularity and massive pumps.  MXAC also contains significant amounts of theobromine; another vasodilator that ups the amount of nutrients and oxygen into the brain and skeletal muscle.  This greater blood flow to the brain contributes to the cognitive enhancement capabilities of MXAC. By blocking adenitric oxidesine uptake without activating adenitric oxidesine receptors, MXAC triggers increased dopamine and serotonin levels which exerts a positive influence on mood and helps the subject maintain an improved state of mind and focus. 

 

Caffeine and Action on Adensoine

 

Another added benefit of MXAC is the ability to stimulate the central nervous system, which helps users of RPM feel more alert - allowing for enhanced focus and clarity.   It also stimulates the neural system to fire muscles into action more effectively via norepinephrine stimulation and by producing changes in calcium activity; stimulating ion transport of potassium into non-contracting tissues. This is important because ion transport helps reduce the increase in blood potassium concentrations during exercise, helping maintain the excitability of the muscle fiber, allowing for a stronger, longer muscle contraction.

 

 Action Potential                                                                       Muscle Contraction

 

 Chocamine®, the other component of the Methyl-AMP Complex, is a specially standardized cocoa extract comprised of several different important constituents that enhance mood, cognitive awareness, and muscle contraction. PEA, tyramine, and L-tyrosine are the most prevalent constituents of chocamine, and have the biggest impact on the positive effects of the compound. The amino acid tyrosine has profound psycho-stimulant effects that improves cognitive function, as tyrosine is a precursor to the neurotransmitter dopamine. Tyrosine supplementation has been shown to increase dopamine and norepinephrine levels, which can be helpful for increasing athletic ability and cognitive function.  Tyrosine also has the ability to ward off exercise-related fatigue by creating a favorable dopamine / serotonin ratio, which can positively alter the subject’s state of mind and reduce mental fatigue.  This simple shift in the amino acid ratio can create a large difference in perception and concentration, and higher dopamine levels are closely correlated with increased focus and mood enhancement/anti-depressant activities.   Tyrosine has also been shown to reduce or prevent stress-related cognitive impairment, and has been attributed with mild suppression of glucocorticoid secretion.

 

        L-Tyrosine                                            Theobromine                                                                     

Phenylethylalanine (PEA) and tyramine are two more important constituents of Chocamine.  PEA is a biogenic amine derived from the aminitric oxide acid phenylalanine, and it has some effects very similar to amphetamine.  It has strong mood-enhancing qualities, along with the ability to increase focus and offset lack of sleep.  Tyramine is another biogenic amine found in Chocamine, and is responsible for the increased release of NE in the neurons, creating an excitatory effect on the CNS.  It has also been shown to increase dopamine levels and increase the generation of cAMP, and also to aid in lipolysis. 

 

Summary

RPM is the first and only product that provides such a unique combination of performance and mood-enhancing effects. The benefits on RPM reach beyond high-performance workouts in the gym, but also promotes personal effectiveness and productivity in all aspects both mental and physical. Try some today!